After a 100-day absence because of the coronavirus pandemic, Aston Villa v Sheffield United will kick off the English top-flight’s resumption.
It is the first of 92 league games that will be packed into a frantic 40 days before the season concludes on 26 July.
Fixtures will be played behind closed doors as one of a host of measures to prevent any further cases of the virus.
A minute’s silence to remember those who have died with coronavirus will be held before the first matches, while heart-shaped badges in tribute to frontline NHS staff will also be worn on kits.
For the first 12 matches of the restarted campaign, all player names on the back of shirts will be replaced by “Black Lives Matter”.
This follows the death of George Floyd in the United States, which has sparked protests worldwide.
Over eight rounds of twice-weekly coronavirus screenings of Premier League players and staff, there have been 16 positive results from 8,687 tests.
Liverpool sit 25 points clear at the top of the table while Bournemouth, Aston Villa and Norwich City are in the relegation places.
The Reds, chasing a first league title in 30 years, could clinch it with victory in their first game back should second-placed Manchester City lose to Arsenal on Wednesday.
Which team do you support and do you think it will get a champions league spot?